1,2,4-Oxadiazoles are heterocyclic compounds that have a remarkable range of applications. This overview focused on investigating the potential and scientific and technological evolution of these compounds through an analysis of patent databases and scientific papers. Prospecting technology using patent databases is an important tool for mapping technologies or technological areas, allowing the identification of such things as trends and investments. The mapping of 1,2,4-oxadiazoles patents and patent applications was facilitated by using different key word from scientific papers found in the INPI, Esp@cenet, WIPO, LATIPAT databases and in the Web of ScienceTM database. The majority of the patent records related to the researched technology had been filed in the Esp@cenet database. A constant linear growth in the number of records of patents granted could be observed over the years, with a remarkable dominance of patents recorded in the USA (24.7%). In addition, when the search through scientific papers was performed, the USA was also the country that had produced the largest number of publications. On the other hand, Brazil presented only two patent grant records (0.2%) and fifty-four published papers related to the technology being researched. In summary, there is great scientific and technological interest in the 1,2,4-oxadiazoles.

Resumo: Partindo das ideias de Bakhtin e inserindo-as no quadro mais amplo dos estudos discursivos, este trabalho analisa os elementos dos gêneros de discurso encontrado em textos de livros didáticos de química. Foram analisados 12 livros de química, destinados a estudantes da 1.a série do ensino médio, de escolas públicas e particulares. Três livros foram recomendados pelo Programa Nacional do Livro Didático (PNLD) 2012 e escolhidos por um número expressivo de professores da rede pública. O conteúdo objeto do estudo foi: ligações químicas. Foi possível identificar recapitulações, chamadas e metáforas (elementos do gênero didático); descrição, classificação, explicação e definição (elementos do gênero científico). O elemento contextualização foi pouco descrito nos livros analisadas. O uso de metáforas foi predominante no livro H.

Abstract: Using the ideas of Bakhtin and inserting them in the broader frame of discursive studies, this paper analyzes the elements of discursive genres found in chemistry textbooks texts. Chemistry twelve books were analyzed, aimed at students of the first high school series of public and private schools. Three books have been recommended by the National Textbook Program ‒ PNLD/2012 and chosen by a large number of public school teachers. The object of the study was content Chemical Bonds. It was possible to identify recaps, calls and metaphors (the didactic genre elements); description, classification, explanation and definition (the scientific genre elements). The context element was just described in the analyzed books. The use of metaphor was predominant in the book H.

4-[3-(aryl)-1,2,4-oxadiazol-5-yl] butanones 4a-e have been reduced to optically active 4-[3-(aryl)-1,2,4-oxadiazol-5-yl] butanols 5a-e with baker's yeast. We subjected the alcohols possessing (S)-configuration to Ferrier' rearrangement with tri-O-acetyl-D-glucal 6 which furnished new unsaturated O-glycosides 7a-e. The crystallographic data of the glycosides 7b confirmed the (S)-configuration for the aglycone portion of the carbon atom.